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In addition to their catalytic functions, GSTs also contribute to MDR through noncatalytic activities, including modulation of the c-Jun N-terminal kinase (JNK) signaling pathway

The treatment may include injections that are given every day for 10 days then tailored as per the patients need and inject regularly every few weeks or months

Type 2 diabetes is a chronic condition that occurs when the body does not use insulin well and cannot keep blood sugar at normal levels

11 An ongoing phase I/II clinical trial (NCT 04585750) has assessed the safety, tolerability, pharmacokinetics, pharmacodynamics, and efficacy of PC14586 administration in patients with advanced solid tumors harboring the p53 Y220C mutation